The fastest ammo that is reliable in your 15-22, is best for defense IMO.
having that said, the .22lr - no matter how much better than other options that aren't guns - is a poor caliber choice for home or personal defense. Anyone buying just one gun with defense in mind is better off with something else, a shotgun being at the top of the list.
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686/M&P9 Pro/M&P15X/M&P15-22
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