Nosler makes loads in the 225gr. Accubond and partition, and the 250gr. Partition. They're rated at 2750fps and 2550fps, respectively. I handload mine with Sierra 225's and Speer 250's. I tried the Hornadays but they weren't very tight at 100yds. I'll work up loads for the spirepoint 250 when I get back from the 'Stan. Very good penetration on that Nosler. That's about what I get on large Whitetails with the Sierra. Exit wounds are around fist-sized and they go down right there. I shot my last deer with it at 385yds or so, and she dropped like a hot rock.