WW296 will Squibb with too light a charge. I experienced this in a 357 Magnum revolver and 125 gr bullets. Had to go with a max listed charge to get rid of the Squibbs. They make an odd kind of sound and then the bullet hits the backstop. Almost no recoil. This was on an indoor range.

With the larger calibers and heavier bullets this is less of a problem because the bullet weight produces more pressure. With 300 gr bullets in the 44 Magnum you can use the start charges with no problem. With the 240 gr and down use the recommended charges by Winchester. In the 500 S&W it should not be any problem and standard primers will probably work fine.

With the same weight bullets from different makers you can get very different pressure using the same powder. So, check with the maker of the bullets for a recommendation. If you get erratic pressures, you will notice on the chrono. Big variation in velocity. I looked in two manuals for the 158 gr jacketed load of WW296 in 357 Magnum and found a 2.7 gr variation. Be careful.