I have several model 60s, including a stainless 2.25" barrel Ladysmith.

Shooting .357 Magnum loads in 'em isn't much fun.

Doable, sure, but (without being in the least inappropriately sexist), not by most women.
My wife has enough trouble with .38 Special+P loads.

Why give your wife a gun that will hurt her or be truly uncomfortable for her to shoot? Load that Ladysmith with .38 Special (non+P) wadcutters, and go from there.

In any case, recoil recovery with .357 Magnum loads is pretty slow in J-frame guns, and unless you believe in the myth of "one shot stops", you'd do well IMNSHO not to give your wife a revolver and loads that she'll never be able to shoot with any speed.

The Model 60 guns are excellent revolvers, and good for CCW and practice, but use loads that are representative of both what she'll use for practice and what she'll actually carry.