I've got a buddy that is into Mounted Cowboy Shooting, he claims you get more Oomph out of the 44-40, he also warns about running round nose bullets in the Henry rifles, since the bullets are basically dropped down the tube. There have been a few magazine explosions from 45LC because round nose bullets are the norm and dropping a bullet onto a round nosed bullet can set off the primer...this is only on the Henry.
He claims the new Winchester rifles are very good and that you pay for what you get. The Uberti rifles I have seen in other calibers have all proved themselves very well.