As others have said, the single greatest red flag to the .22 RF as an SD round is the relatively large number of failure-to-fires, they suffer. The priming I believe, is spun into the case rim and many .22 RF duds will indeed fire if you rotate them a bit to bring up a fresh piece of rim under the firing pin. That's because there was a piece of rim without priming.

Every time I go to my outdoor club/police range, I pick up a dozen or more dud 22s, most of which fire on the second strike.
With a revolver, you merely need to pull the trigger a second time if you train yourself to do so. A semi auto requires a stoppage drill, even with second strike capability as you can hammer that cartridge all day and nothing will happen.