The load you and your gun shoot the best.
Accuracy counts and a fast follow up shot is not a bad thing !.
Get a selection of suggested ammo and go to the range, let your targets and shooting feelings guide your selection. And with fixed sights, choose something that shoots close to point of aim. They are usually regulated to standard velocity 158 grain loads. Kentucky windage in a defensive situation is not the best thing. Only hits will save you.
Gary