What are the best calibers to stop some guy built like Arnold was at his prime or a fat assailant with a 50-to-54 inch plus waistline? If penetration counts would 45 Colt or 454 Casull out of my Ruger Alaskan 2.5-inch barrel or my S&W 460 (8'3/8) be considered overkill or self defense? I've seen fat guys shot with 9mm that never penetrated beyond the layers of fat to reach any muscle or vital organs. My LE friends say "family comes first, jury selection comes second"...bigger is better unless you live in an apartment building, etc.