I have made countless number of head shots on wounded deer in my 25 year police career. Always one shot, always devastation. Also finished off a 385 lb black bear with a shot to the back of the head. Also stopped several large attacking dogs with one shot.

I have no doubt that any round will stop a human threat if impact is center mass or in the head or neck. Practice head shots at the range guys, in case the threat is wearing body armor.

__________________
MSP - Retired