Before I begin, I remove the grips. Some solvents will strip the finish. With the grips removed, you can oil the frame before reassembly. I've seen way too many guns with corrosion under the wood.

I also remove the cylinder for cleaning. I find the process easier without the cylinder flopping around. You can get the cylinder cleaner off the gun. You can put a drop or two of lube on the yoke before reassembly.