Jim: I don't have direct experience in stopping bears, especially big ones. My area of expertise, if I have one is in behavior. However, based on the one charge I experienced while doing field research (and a few terrified bears going in the opposite direction), you would be EXTREMELY lucky to get more than one shot off during a true charge.

I do not have experience with the 10mm but do have a fair amount with a 41 mag. If the loads are comparable, I would consider it marginal (of course, shot placement is key). Our guys in Alaska use 12 gauge with Brenneke slugs for bears.

Personally, I carry a 454 or hot 45 when in bear country.

Take my opinion for what you paid for it!