Groo here
5gr Bullseye ............
With 230gr jackets, WW2 mill spec load.
With 200gr jackets , JMB original speed 45acp load.
With 180gr target loads. [my go to load with most weights.]
In an S&W 25/325/625 revolver you can go lighter, or heaver with no feed or functions issues.
[Groo like]
As the S&W will shoot 45 super and has been converted to 460 roland
I don't worry about heavy 45acp or 45 +p loadings...