I suppose considering what I have read here, if I HAD to carry a .22 handgun for self defense(a choice I hope never to HAVE to make) I think my choice of ammo would either be CCI Stingers(I HAVE shot those and they're plenty hot) OR a choice that doesn't seem to be very popular for whatever reason and that is the Aguila Super Extra. My choice of handgun would be even more limited as I don't like Walthers in that caliber so I would have to go with the Baretta Bobcat because I just can't think of a more reliable 22 handgun and because I'm not fond of revolvers. Since I DO have a choice, at least at present anyway, I will simply carry my FN57. I love having 20 rounds in the magazine, and the 5.7x28mm TEARS UP everything it hits.