You could read this same thread over on some of the shotgun boards with 'Winchester 21' in place of Colt Python.

They go round and round with the same points to no end comparing the highly priced 21 to any number of other SxS's.
The 21 has the same cult type following it seems and those that like them really, really like them. Others find problems with it and site the high prices for them as totally unrealistic.

You have to decide for yourself,,and we have that right to still buy what we want. The market decides the price so I guess the Python and the 21 are very popular guns on that point alone.

Python Worth it?,,to me personally no, but I just never warmed up to the Phython style with the vent rib. Doesn't make it a bad revolver. I've owned plenty of old style DA Colts and in good condition they are a joy to shoot.
I particularly liked a very early OMM38 and a Model357. Both down the road now for other things I can't recall.