22 shot shell ammo is not made for auto loaders and will jam most auto loaders. IMO it is best to shoot them through a revolver or single shot rifle. The shorter the barrel the less effective shot shell ammo is. Even then you need be really close to the intended target.

I know for fact, by experience, that shooting a snake in a tree with 22 shot shell in a 6" revolver can take a lot of shots fired to drop the snake out of a tree. Now a 12 gage with buckshot will definitely do the job.