In big bore revolvers generally, I prefer a heavy for caliber all lead SWC at modest velocity. Easy to shoot, good performance, adequate penetration (too little is worse than too much most of the time). The only exception is 45ACP, in which I generally would use 45ACP service JHPs just the same as in the self loader. I did find and buy a decent quantity of the Speer .44 Special Gold Dot in Blazer cases; decent performance and reasonably shootable even in my 296. (Less rank than a hot .38 or 9mm in a J frame.)

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NHI, 10-8.