There are numerous .380 self defense rounds that are more than adequate. When I carry my .380 I use the Corbon Pow'RBall round which is a really nasty round. Most of the time I have my Shield with me but I do have a Bodyguard and Sig P238 that I sometimes carry. Any gun is better than none at all. I've seen a number of studies that concluded that the differences between round effectiveness isn't all that great and of course it depends upon placement more than anything else. For home self defense, I wouldn't use by Colt 45 or my S&W .357s, I would just grab my AR15 and be done with it. Regards, Elliot45