While you can use 4227 in the .357, I guess I would not (can tell you for a fact I do not).

A better choice to consider would be 2400. It is easy to work with, give you wide latitude in loading unlike H110/296 which are top end only powders. You can also use it in your 44, M1 carbine and .22 hornet, .41 mag - - -

Lots of history, lots of loads available.