I have medium-small hands, and i prefer rubber grips on my k-frame 357 revolvers for work, and wood for showing off. I prefer pachmayr gripper grips as they cover the backstrap and fit my hand. Rubber grips will never look as good as wood/horn/ivory grips. But all will trap moisture if they are properly sealed. You don't want your wood grips soaking up water and oil, so you should seal them to prevent that. As for the frame, keep it either waxed or oiled, and be sure to remove the grips to clean and re-protect the frame at least once a year.