My first round would be the same as the rest of the rounds.

In theory , no1 Buck would be best balance of pattern density and pellet size . But alas it is rare on the shelf in my area, and Federal Tactical 00B is plentiful, so that what I usually roll with. If you were speaking literally in the home, 4B would be more or less viable , but for my rural home, front door to end of driveway is close to 50yds.

No, I'm not volunteering to take a load of #8 to the face at close range. But the various birdshot has reallly, really shallow penetration, and I'm not even a penetration obsessed guy. Like 1-2 inches of pnetration. Unless I'm mugged while dove hunting ( actually a real thing) , I'll pass .