I have used all three in my 45colt Mt.gun. I bought the Colt as it was slightly lighter and handier for all day, everyday carry. I found the 45 better suited for low to midrange loadings say 800 to 950 fps than the same in 44. For myself, Unique feels more like a blackpowder shove than the snap of the other two powders. This is why in these large volume cases I have settled on Unique. Always availabe, always consistent, and a margin of safety.