I generally prefer autopistols for ergonomic reasons. However, I am reasonably confident that sound hits with the standard velocity .38 SWC will do about as well (or poorly) as any other handgun service round. Remember that handgun rounds suck, and that handguns are what one carries when there is no reason to expect a problem. Take a good look at the sound research and writing on the issue from Doc Roberts (quoted on the first page; he's the heir to Dr. Fackler) and the excellent chapter on the issue from Patrick and Hall in the latest edition of their book - then planning on shooting as fast and accurately as you can until you perceive that the offender is not capable of the actions that justified shooting him (or her) in the first place.

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NHI, 10-8.