The only problem with the Python is that when one eventually gets out of tune, it's rough to find a gunsmith who knows how to treat the old leaf-spring Colt actions. Easy to find smiths that can work on Smiths and 1911s, but Colt revolvers are now just rare enough that knowledgeable smiths are few and far between.
The one Python I own is supremely smooth with no post-factory work, although I have a Nelson Ford-tuned S&W 625 .45 ACP that comes darn close. I don't use the Python but rarely, while the 625 is used fairly often with no fear.
John