I will add my two cents, having owned all three of your considerations. I carried a Glock 29 Gen 3 for about a year, ended up getting rid of it for a Glock 32. The 29 was a brick, didn't offer any advantages over the 32, so I made the change. A gen 4 29 might be better, but it wasn't out at the time. Last year I bought the 627PC, great gun , a bit top heavy with the included grips but certainly no harder to carry or conceal than the 29 was. I ended up trading the 627 for a 586 L-comp. While the weight was almost identical, about 36.6 vs 36.7 ounces, the L frame felt much better in the hand and carries much better IWB, for me, and I'm a big guy with big hands. I'm not too concerned with the loss of a round, if I was worried about capacity I probably wouldn't be carrying a revolver anyway. As far as ammo, defense ammo is about the same price regardless of caliber, but range ammo in 38/357 is much more abundant and cheaper everywhere I've ever shopped. Hope this helps to some degree.