Variations can cause variations in crimp, which isn't good for 110 in .357s.

Also, 110 is good for HEAVY loads. If you are getting some erratic burning I'd try using one of the 'lighter' magnum powders like 2400 or Acc 9 that are more amenable to downloading as well as having more of a full load to get the velocities you are after, which is more conducive to better burning.

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