I can easily operate a revolver with one hand. Hard. but not impossible to rack an auto one handed. Lots of different types of injuries and disabilities, Just because one can't rack a slide doesn't mean they can't work a 12# trigger. Problem might be with the thumb or forefinger of the off hand. I will admit racking a slide is mostly just grip cause if you can hold on to the gun and slide its all arm power from there. Once loaded most semis only need a safety release or on the DA models about the same trigger pull as a revolver.

To me the semis only have one advantage. Capacity. If you practice like you really should a double action trigger isn't a disadvantage. Size and weight of anything bigger than a tiny 380 is a toss up.

Hard to find a semi auto big bore lighter than my 396 or 325 though.