I think that Cowboy4ever spoke words of wisdom about your leading problem.
I personnally use Unique for honest to God 45 Colt loads and IMR 4227 with mag primers for my Oh my God loads(Ruger Blackhawk loads).
I do not like Titegroup;it tends to burn at a high temp.If you want a quick burning powder for target loads,the usual ones are all good(Red Dot,700x,Bullseye,Promo,231 and some more).