I have several 45 Colts, including a 25-5. When the powder shortage hit a couple years ago I tried to convert all my handguns to Bullseye, since I had an ample supply.

I ended up switching back to Unique when I was able to get some. 45 Colt, 41 Mag and 357 Mag will work with Bullseye, but they simply work better with Unique.