"I have some removable locktite that I am going to apply from the rear of the screw to hold it in place. Haven't done so yet, but don't see why that would not work well to keep the screw from working loose under recoil. "

I had thought of the same thing to hold the cylinder release screw in position except I was thinking about applying a dab of Super Glue instead of Loctite. It's not under any particular stress, so the Super Glue should hold. Also could be easily dissolved by Acetone if needed. My original intent was to reload with some 180 grain .44 bullets which I thought I had some of, but when I looked, I had only the 240 grainers. So I used what I had. For sure, I will not be loading any more 240 grain bullets for use in the Bulldog.