In shotgun loads I prefer Winchester primers. For everything else, I use only Federal, and not because of the belief that some highly-tuned revolvers require them. None of my guns are setup that way. I prefer them because I always have had good luck with them.
In certain small cartridges (generally the .32s) I use Remington 1-1/2s, but everything else gets Federals only - unless I can’t get them. The 1-1/2s probably aren’t really necessary, but old habits are hard to break.
If there is a drawback, it’s sure the enormous packaging.
I’ve never seen any actual test results that document that Federal primer cups are softer than others.