Sure. I have a 6.5" 629. I load 11 grains of AA#5 under a 240 grain SWC. Haven't chronoed it, but published data (extrapolated from .45 Long Colt) indicates around 1050 or 1100 fps.

Very accurate, pleasant to shoot, but you still know you're shooting more than a .44 spl. I call it Magnum Lite.