It wouldn’t affect the loosening problem but I’d think those slots should have been machined with a full radius in the bottom.

Overall, it doesn’t appear to be the best design. I do not own one of these guns but have seen them in shops. I’m curious. How is the comp indexed radially? Without some sort of stop or key between the comp and the barrel, attaching it with only one screw definitely is asking for trouble. I would certainly use Loctite. Unless the gun gets to a temperature well beyond too hot to handle the Loctite should be effective.