OP: If you can find a NIB Python for "$2200" you should jump on it. That would be a hell of a good price.
Having said that, I've owned both. The S&W DA trigger is considerably better. The single action Python trigger is insane though and the action feels like it was made by a Swiss watch maker. That said, if they were all the same price, I'd take the 686. Now as an investment, definitely the Colt.