I have a 686 no dash and a Ruger GP100, both which I bought in the 80s, both with 6 inch barrels.
I finally bought a Python shortly before Colt quit making them, also in 6 inch.
If I was going to use it as a truck gun I would pick the Ruger. The S&W is better for target shooting. The Python is lovely but these days it is like you want an armed guard with you if you take it to a public range to try and shoot it. The prices on them have become silly. Mine was about $1K new ordered through a LGS a little before Colt quit making them.