While I wouldn't describe the .380 ACP cartridge as "powerful" per se, it is most certainly adequate.

I carried .380 ACP as my primary Self-Defense cartridge for years, and only upgraded to .40 S&W due to sightings of wild, potentially rabid animals in my area which I wasn't confident in the .380 ACP's ability to stop. Heck, most folks probably think that .40 S&W isn't enough either, but seeing as it's a dual-purpose weapon for EDC, I can't justify carrying a Magnum Revolver everywhere.

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Shooting Comfort is bilateral.