In my Ruger factory convertible 45 with both cyls. I couldn't tell the difference once the chamber throats were opened up and properly sized in the Colt cyl. It took a slightly hotter load for best accuracy with the 45 Colt cartridge: volumetric efficiency in the larger case.

I wouldn't be surprised if the same thing were true in a convertible S&W revolver.

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Jim
S&WCA #819