For OWB carry in a holster covering the trigger guard, I keep a round chambered in the Glock 19. When stored within easy reach in the bedside dresser for home defense, I keep it unchambered with a full mag, so I don't have to worry that I might fumble and negligently discharge in the process of removing it for something that goes bump in the night, or when the dogs alert. Having to deliberately rack the slide requires me to shrug off sleep and become fully alert to the possiblity of a threat. It goes without saying that with any firearm, always keep your finger outside the trigger guard until ready to fire.