Do you have anything that shoots well in your rifle now? For me it is Federal American Eagle Varmint & Predator which is a 50 Grain JHP at 3325 FPS. This will shoot three shots touching in a 4.5 inch bull at 100 yards off the bench. To get reloads to shoot the same grouping a friend and I did some testing (read lots of shooting). We used Sierra 52 grain HPBT's and several different powders. Would pick a loading that approximated the Federal loading (used Quick Load on the computer to get a rough idea of what we wanted). Then we would load groups of rounds (15) that were a couple of 1/10's above and below the recommended. Tossed out the ones that did not group well and worked with the ones that did. Ended up with 25.4 grains of H335 with the 52 grain Sierra HPBT that duplicates the same accuracy in my rifle.

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USMC 69-93 Combat Pistol Inst.