If you have good bullet fit, a pretty soft bullet can be used without any leading problem.

Some years ago, the editor of the Cast Bullet Association magazine mentioned something to this effect in an editorial: the softest bullet that can be fired at the desired velocity without leading the bore will almost always provide the best accuracy.

This, of course, requires experimentation, but serious bullet casters know all about that. The editor was referencing rifle loads, but I think the same would apply to handgun cartridges as well. There are exceptions to everything, but I've always found this to be generally good advice.