I shot a 4-inch barrelled .500 once.....my entire hand tingled for a few seconds! The owner that loaned it to me laughed but I wasn't offended.

I have a friend that carried a Desert Eagle .50 AE concealed for many years and used it to stop several crimes and even held offenders at gun point until police arrived. He's a big guy and carried it in a sort of makeshift shoulder holster.