I'm now not so sure I could. S&W's webpage no longer shows the 6-1/2" X500 as available ... only two are listed: a 4" and an 8-1/2". The 4" weighs 55.6 oz, versus 44.7 for my 5" 629. That's a bigger difference than I expected. I could probably carry it in my homemade cloth shoulder holster rig, but I would probably be well aware of its weight, and probably wouldn't be completely comfortable carrying it all my waking hours like I am with my 5" 629.