The variables you introduce in your OP are the problem. There are just too many contingencies in these scenarios to come to any inflexible and single conclusion relating directly to the firearm or ammunition of choice. Just impossible to answer all of the "what ifs" that invariably enter in to this kind of discussion.

Physiologically speaking, if you are able to impart significant damage to the brain, or brain stem, there will be no response from the person or animal on which the damage was inflicted. The fight is over, whether the injury was caused by a .22 rimfire projectile, a 10mm projectile, or an iron skillet.

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Ret. LE, FA Instr, S&W Armorer