Asking my favorite single bullet/powder combo is much like asking my single favorite song ever — can’t do it!

However, I will name one that never lets me down, and one I never deviate from. It was a very easy one because it’s legendary and it came long before I was rolling my own:

.38 Special, swaged lead hollow base wadcutter, 2.7 grains Bullseye, and a light roll crimp. Used mostly in my 52’s, but also fantastic in my PPC revolvers.