My latest Hornady manual lists 10.7 gr of Unique as the top load with a velocity of 1200 f/s, NOT out of a test barrel.

Decades ago I used Remington 240 gr JHPs loaded at about 1100/1150 f/s to take a number of deer with one shot kills. Yeah, factory ammo was faster, but the hand load groups were 1/2 the size of factory groups way out there. I've never shot any critters with XTPs, but media testing suggests Hornady prioritized penetration over expansion. All my shots with the Remingtons were quartering shots and penetration wasn't an issue.

Should you run across some IMR/Hogdon 4227, it's a very good choice, but magnum primers are suggested.