.45 is a lousy caliber. Here is actual documented proof.
A Skokie cop shot a bad guy 17 times with a .45; after the shooting he switched to a 9mm.

“There were 17 total hits on his body including three fatal shots to his head, a couple to his torso, and one to his abdomen," Gramins says. "Which means that even though Maddox was mortally wounded before the head shots, he was still able to engage me.

"People don't die the way we think they do," Gramins says. "I had 17 rounds in the guy. That will teach you how critical shot placement is."
Shots Fired: Skokie, Illinois 08/25/2008 - Patrol - POLICE Magazine