I'd consider it something of a waste of commodities.
Unique is a good powder behind traditional cast lead in the 44 magnum. However nearly 290 grains of cast lead is well above it's pay grade.
If it is in fact Unique, the charge weight stated is ridiculously high.

I wouldn't bother duplicating such a theoretical load.
Above 250, one should consider the projectile "business class" and load accordingly. Its not meant to to a back yard plinker
even a 240 grain is gray area in my school of thought ... 200 - 225 or so ... why yes ... these do light to mid range loads with aplomb

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it just needs more voltage