Years ago I sold my 649 .38 Special because I just had to have a .357 Magnum version. I carried .38 Special +p ammo in my new gun but I always wondered how it would shoot with full power .357 Magnums.
I was also concerned with how this gun/hot ammo combination would work out if I was unable to use my right hand and had to shoot left-handed.
This video answered both of my questions.
I try to shoot with my weak hand at least once a month.
I did not try this experiment with my Model 340 PD.