Interesting responses I guess.. my 4566 with straight delrin grips is the only handgun I’ve ever shot that I hated how it handled - which came as a surprise given my love for my other 2nd and 3rd gen’ (with straight and curved grips). I wouldn’t categorize my hands as particularly small or large, but maybe I just have proportions that don’t work with the factory grip on the 4500 series. The gun would still point well for me but after a few shots I was always stopping to regrip the gun.