Never really tried any "hard target barrier testing" with a .45 acp, but I did work up a load to carry for deep penetration while camping and traveling in the black bear / moose woods. It is a hard cast WFN type bullet that casts out to about 240 grains. I push them with a warm load at about 950 fps. I have gotten thru and thru penetration on a couple whitetails I have shot with this load, and figure it should penetrate about any barrier a .45 acp is going to be able to.

A good source for a non reloader might be one of the small specialty manufacturers like Buffalo Bore, etc.

I am thinking because of higher velocity, and better bullet sectional density, a 10mm with a similar bullet would penetrate better. I don't know typical jacketed FMJRN's bullets hold together better than a properly hard cast and water hardened lead bullet. Most FMJ handgun bullets are of thin jacket and soft lead cores. They can deform when hitting something hard, limiting penetration.

Larry