"Hard Target" sounds like an Internet-era term even though it's meaning is clear, but what about the old Remington Hi-Way Master .45 ACP load from years ago? That was a 173 grain pointed jacketed bullet loaded to around 1140 fps. Wouldn't that do about anything from a penetration perspective that more modern cartridges would do? It certainly would seem so and it's pretty close to 10mm Magnum ballistics.

There was also a Peters loading .45 ACP loading that was the same or similar and Winchester Winchester loaded a 230 grain conical jacketed bullet to well over 900 fps during the same era. There may have been others.